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ambien side effedts "This is, at the end of the day, an inflammatory hormone that people will be on for many years," Wilson said. "It makes sense for congenitals who have low levels [of leptin] that they clearly ... gained tremendous benefit. But the long-term exposure, the potential for neutralizing antibodies, and a lack of clear evidence of benefit makes me feel" the risks may outweigh benefits for partial lipodystrophy patients.